Purdue researchers created a drug to fight one of the most deadly cancers

Purdue researchers are working on what could be known as the next medical breakthrough in cancer treatment

Posted: Jan 27, 2019 8:01 PM
Updated: Jan 27, 2019 11:42 PM

WEST LAFAYETTE, Ind. (WLFI) — Purdue researchers are working on what could be known as the next medical breakthrough. Right now, cancer is the second leading cause of death, but who knows if that'll be true a few years from now.

Professor Herman Sintim with Purdue's Department of Chemistry is working to reduce deaths caused by Acute Myeloid Leukemia.

“I am interested in Acute Myeloid Leukemia because it has one of the worst prognosis,” said Sintim.

To put it in perspective, if 100 people were diagnosed with AML right now, only 30 of them would still be alive in five years. And that number drops to 10 if you're over the age of 60.

“Clearly there is a need to come up with new drugs or new therapeutic modalities that improve the survival of Acute Myeloid Leukemia,” said Sintim.

AML is an aggressive cancer that attacks blood cells, which fight infections and diseases in our body. With AML, an infection as common as the flu could be deadly.

“We as molecular scientists developed chemicals that bind to this protein that drives the cancer, to shut the protein down,” said Sintim.

By shutting down the protein, the new drug is essentially slowing down the growth of the cancer.
This gives the blood cells a chance to gain strength and fight off all the infections in the body.

“Two years ago we realized that a few of our compounds were actually really good at killing the cells in a test tube and so that is when we transitioned to test the compounds in an animal model, which is mice,” said Sintim.

The compound cleared the cancer from the mice.

“That was when we knew that perhaps, we had developed something that not only works in a test tube but also works in an animal,” said Sintim.

The next step is a clinical trial. Sintim believes this drug has the potential to save many lives.

“If we can extend, you know, life by a few months, a few years or even a few decades, it would have far-reaching implications,” said Sintim.

The results of the study were published in the EBioMedicine journal Friday, Jan. 25. The website is globally recognized as a prestigious journal for up and coming drugs and technology.

West Lafayette
Clear
77° wxIcon
Hi: 85° Lo: 66°
Feels Like: 79°
Kokomo
Clear
71° wxIcon
Hi: 83° Lo: 63°
Feels Like: 71°
Rensselaer
Clear
72° wxIcon
Hi: 82° Lo: 65°
Feels Like: 72°
Fowler
Clear
72° wxIcon
Hi: 82° Lo: 65°
Feels Like: 72°
Williamsport
Clear
74° wxIcon
Hi: 83° Lo: 66°
Feels Like: 74°
Crawfordsville
Clear
67° wxIcon
Hi: 82° Lo: 66°
Feels Like: 67°
Frankfort
Clear
66° wxIcon
Hi: 83° Lo: 65°
Feels Like: 66°
Delphi
Clear
76° wxIcon
Hi: 85° Lo: 65°
Feels Like: 78°
Monticello
Clear
76° wxIcon
Hi: 86° Lo: 64°
Feels Like: 78°
Logansport
Clear
70° wxIcon
Hi: 82° Lo: 63°
Feels Like: 70°
Warm Weekend Continues Sunday
WLFI Radar
WLFI Temps
WLFI Planner

Indiana Coronavirus Cases

Data is updated nightly.

Confirmed Cases: 72254

Reported Deaths: 3023
CountyConfirmedDeaths
Marion15503725
Lake7447274
Elkhart476082
Allen3789161
St. Joseph337381
Hamilton2668105
Vanderburgh188813
Hendricks1833106
Cass17749
Johnson1719118
Porter126639
Clark117846
Tippecanoe117711
Madison91565
LaPorte88330
Howard87265
Kosciusko84012
Marshall77122
Bartholomew76647
Floyd76045
Monroe72230
Delaware70152
Dubois67612
Boone66246
Noble65929
Hancock64138
Vigo58610
Jackson5725
Warrick57030
LaGrange55610
Shelby54227
Grant52130
Dearborn49328
Morgan45934
Clinton4093
Henry37320
Wayne35410
White35410
Montgomery34821
Lawrence33627
Decatur33232
Harrison32123
Putnam2868
Miami2672
Daviess26320
Scott26310
Greene24634
Franklin23813
Jasper2272
DeKalb2264
Jennings22012
Gibson2144
Steuben2063
Ripley1977
Fayette1837
Perry18112
Carroll1772
Starke1767
Posey1670
Orange16624
Wabash1633
Wells1622
Fulton1612
Jefferson1552
Whitley1506
Knox1490
Tipton1336
Spencer1313
Washington1311
Huntington1213
Newton11510
Randolph1154
Clay1095
Sullivan1031
Adams952
Jay860
Owen841
Pulaski761
Rush744
Brown731
Fountain682
Blackford622
Ohio624
Benton600
Pike520
Parke511
Vermillion500
Switzerland450
Crawford440
Martin430
Union370
Warren221
Unassigned0202

COVID-19 Important links and resources

As the spread of COVID-19, or as it's more commonly known as the coronavirus continues, this page will serve as your one-stop for the resources you need to stay informed and to keep you and your family safe. CLICK HERE

Closings related to the prevention of the COVID-19 can be found on our Closings page.

Community Events