SEVERE WX : Winter Weather Advisory View Alerts

Pfizer's Covid-19 vaccine appears to work against mutation in new coronavirus strains, study finds

CNN's Dr. Sanjay Gupta looks at the increasing number of Covid-19 cases and deaths in the United States and explains why health experts are unsure when these numbers will peak.

Posted: Jan 8, 2021 6:40 PM
Updated: Jan 8, 2021 6:40 PM

A new study provides early evidence that a Covid-19 vaccine might be effective against two new coronavirus strains first identified in South Africa and the UK, despite a concerning mutation.

The two strains share a mutation known as N501Y that scientists worry could allow the virus to evade the immune protection generated by a vaccine.

In research posted online Thursday, scientists found that antibodies from people who had received the Pfizer/BioNTech vaccine showed "no reduction in neutralization activity" against a version of the virus that carries the N501Y mutation, which they created in the lab.

In order to do this, researchers tested the virus against blood from 20 people who had received two doses of the vaccine as part of a clinical trial.

The N501Y mutation is located in the coronavirus' spike protein -- the same structure targeted by vaccines. The virus uses this protein to enter the cells it attacks.

This particular mutation appears to help the virus attach to human cells, which may partly explain why these new strains appear to be more transmissible. But it is just one of many mutations in both strains that scientists have worried could make the virus less susceptible to vaccines or treatments.

The study -- conducted by researchers at Pfizer and the University of Texas Medical Branch -- does not test the full array of these mutation, nor has it been peer-reviewed.

While viruses are expected to mutate -- often in ways that are neutral or even harmful to the virus -- experts say the whole is not merely the sum of the parts: Some mutations are known to interact with one another, occasionally changing the shape or function of structures like the spike protein.

"A limitation of this study is that the mutation was tested in isolation," Deborah Dunn-Walters, chair of the British Society for Immunology's taskforce on Covid-19 and immunology, said in a statement. She noted that mutations that may have a compound effect "should be tested together."

Because people usually make more than one type of antibody against a virus, experts say it's unlikely such a mutation would render the virus completely resistant to a vaccine. However, experts aren't so sure the new strains will have no impact at all.

"We will need to see actual protection from new variants in participants in the clinical trials that are still running to be sure the vaccine is equally effective," Alexander Edwards, associate professor in biomedical technology at University of Reading's school of pharmacy in the UK, said in a statement. Neither Edwards nor Dunn-Walters was involved in the new research.

If a virus is more transmissible or less susceptible to a vaccine, experts say that could also raise the bar for the number of people who would have to be vaccinated to achieve herd immunity.

In a statement last month, Pfizer said it had performed similar tests on "multiple mutant strains. To date, we have found consistent coverage of all the strains tested."

It will be important to continue "monitoring of the significance of changes for vaccine coverage," the researchers wrote in the new paper.

That's because of "the possibility that a future mutation ... might necessitate a vaccine strain change." Both Pfizer's and Moderna's vaccines use genetic technology that would allow the vaccines to be quickly adapted to account for mutations, they noted.

In a statement Friday, BioNTech said it and Pfizer "are encouraged by these early, in vitro study findings," but stressed that "further data are needed" to track the how effective the vaccine is at preventing disease caused by new variants.

Lafayette
Partly Cloudy
31° wxIcon
Hi: 33° Lo: 27°
Feels Like: 23°
Kokomo
Cloudy
29° wxIcon
Hi: 31° Lo: 23°
Feels Like: 19°
Rensselaer
Partly Cloudy
30° wxIcon
Hi: 31° Lo: 28°
Feels Like: 20°
Lafayette
Mostly Cloudy
31° wxIcon
Hi: 32° Lo: 28°
Feels Like: 20°
Danville
Cloudy
30° wxIcon
Hi: 33° Lo: 28°
Feels Like: 19°
Frankfort
Cloudy
28° wxIcon
Hi: 34° Lo: 27°
Feels Like: 17°
Frankfort
Cloudy
28° wxIcon
Hi: 32° Lo: 26°
Feels Like: 17°
Monticello
Partly Cloudy
29° wxIcon
Hi: 32° Lo: 26°
Feels Like: 20°
Monticello
Partly Cloudy
29° wxIcon
Hi: 32° Lo: 28°
Feels Like: 20°
Logansport
Partly Cloudy
28° wxIcon
Hi: 32° Lo: 25°
Feels Like: 28°
Active Start To The Work Week
WLFI Radar
WLFI Temps
WLFI Planner

Indiana Coronavirus Cases

Data is updated nightly.

Cases: 611039

Reported Deaths: 9716
CountyCasesDeaths
Marion844351336
Lake45508685
Allen32891552
Hamilton29546315
St. Joseph27449381
Elkhart24440345
Vanderburgh19513250
Tippecanoe18043140
Johnson15140295
Porter14865169
Hendricks14440248
Madison11009222
Vigo10769181
Clark10731144
Monroe9424113
Delaware9152134
LaPorte9103164
Howard8268144
Kosciusko808983
Warrick676599
Hancock6741104
Bartholomew6523100
Floyd6469110
Wayne6157162
Grant6011116
Dubois556980
Boone554668
Morgan545795
Henry509764
Marshall505384
Cass485264
Dearborn483245
Noble474059
Jackson426747
Shelby419581
Lawrence392980
Clinton374243
Gibson372559
Harrison350945
DeKalb348264
Montgomery346554
Knox335839
Miami323044
Steuben314545
Whitley309726
Wabash304551
Adams302136
Ripley300046
Putnam297850
Huntington293159
Jasper290534
White274143
Daviess271274
Jefferson264738
Decatur248983
Fayette247848
Greene241162
Posey240328
Wells236451
LaGrange229662
Scott225739
Clay223532
Randolph214948
Jennings199336
Sullivan192933
Spencer192422
Washington187523
Fountain184627
Starke175643
Jay168223
Owen166837
Fulton164230
Orange160835
Carroll159115
Rush155818
Perry155229
Vermillion149334
Franklin149033
Tipton133033
Parke13088
Pike118226
Blackford111422
Pulaski97337
Newton91721
Brown88235
Benton86910
Crawford8069
Martin74413
Warren6857
Switzerland6665
Union6287
Ohio4957
Unassigned0376

COVID-19 Important links and resources

As the spread of COVID-19, or as it's more commonly known as the coronavirus continues, this page will serve as your one-stop for the resources you need to stay informed and to keep you and your family safe. CLICK HERE

Closings related to the prevention of the COVID-19 can be found on our Closings page.

Community Events